KScribe Regulatory Writing

    The regulatory writing platform for the entire trial lifecycle.

    KScribe authors, validates, and keeps every clinical and regulatory document in sync, from protocol to submission. Months of medical writing, delivered in days.

    Trusted controls: SOC 2 Type II HIPAA ISO 27001
    KScribe Drafting In sync
    Documents
    Protocol Drafting Done
    IB Queued Done
    ICF Queued Done
    SAP Queued Done
    CSR Queued Done
    DSUR Queued Done
    Waiting on Protocol
    All documents in sync
    Protocol KT-204 · v0.3 ICH E6(R3)
    Drafting protocol Generation complete
    2.1  Study Objectives & Endpoints

    Primary objective: evaluate treatment effect on the prespecified clinical endpoint.

    Secondary endpoints include safety, tolerability, and exploratory biomarker response.

    Endpoint definitions are aligned to protocol v0.3 and ICH E6(R3).

    ICH E6(R3) NCT024… Protocol v0.3
    Validated against ICH E6(R3) §6.2 In sync
    90%
    faster first-draft creation
    20+
    document types supported
    Days
    to submission-ready, not months
    100%
    source-traceable statements

    KScribe writes the entire regulatory record, not one report.

    Point tools generate a single deliverable in isolation. KScribe is an enterprise platform that authors and connects every document across the trial, so the whole submission moves as one.

    01Source data
    Protocol
    Previous studies
    CSR
    SOPs
    ICH Guidance
    Sponsor Library
    Clinical Data
    02Study intelligence
    Knowledge graph Evidence layer
    03Drafting
    [1]
    [2]
    04Live validation
    ICH E6(R3)
    CDISC
    Terminology
    Completeness
    Consistency
    05Human review
    MW
    Approved 2 comments
    06Connected documents
    Protocol
    Investigator Brochure
    ICF
    SAP
    CSR
    Submission Package
    One source of truth

    Every document drawn from the same study intelligence.

    One connected record
    Hover any document to see how KScribe keeps it aligned with the rest of the study.
    How KScribe works

    An authoring pipeline, not a chatbot.

    KScribe runs retrieval, drafting, validation, and propagation as a governed pipeline. Every section is grounded in evidence and checked against the rules before a human ever opens it.

    01

    Ingest

    A concept, synopsis, prior data, or sponsor library: KScribe extracts indication, design, and regulatory pathway.

    02

    Ground

    Retrieval over ICH guidance, precedent documents, and your evidence base, so nothing is written without a source.

    03

    Draft

    All standard sections authored in parallel with inline citations, CDISC tagging, and consistent terminology.

    04

    Validate

    Every section is checked live against regulatory rules and internal style before it reaches a reviewer.

    05

    Propagate

    Change an endpoint once and KScribe cascades it across every linked document, with no manual reconciliation.

    06

    Co-review

    Your team comments in-line; KScribe regenerates affected sections and keeps the audit trail watertight.

    Capabilities

    Built for the regulated reality of clinical writing.

    Guideline-aware drafting

    ICH, FDA, and EMA conventions are enforced as the document is written, not patched in afterward.

    Cross-document consistency

    One change updates every linked document. Endpoints, eligibility, and terminology never drift apart.

    Source-grounded citations

    Every claim traces back to protocol, study data, or guidance, ready for QC and inspection.

    Sponsor-library aware

    Inhales your past protocols, MOPs, and style guide. Future drafts inherit your terminology and structure.

    Live regulatory validation

    Compliance and completeness checks run continuously, flagging gaps as sections are written.

    Version & audit control

    Every edit is logged and every draft is reproducible, with a defensible trail from first word to filing.

    Regulatory intelligence

    Fluent in the standards your filings are judged against.

    KScribe authors to current ICH guidance and agency expectations, tags data to CDISC, and assembles output that drops into an eCTD submission, with the reasoning behind every choice on record.

    ICH E6(R3), E3, E2C/E2F authoring conventions
    FDA, EMA, and PMDA submission expectations
    CDISC tagging and eCTD-ready structure
    ICH E6(R3)
    Good Clinical Practice
    ICH E3
    CSR structure
    CDISC
    Data standards
    eCTD
    Submission format
    Supported documents

    One platform across every phase of the trial.

    From startup through submission, KScribe authors the deliverables your teams write today, and keeps them connected.

    01
    Study Startup
    5 DOCUMENTS
    02
    Trial Conduct
    3 DOCUMENTS
    03
    Safety & Pharmacovigilance
    3 DOCUMENTS
    04
    Reporting & Submission
    3 DOCUMENTS
    Synopsis & Feasibility
    Concept to design
    Protocol
    ICH E6(R3)
    Protocol Amendments
    Version-controlled
    Investigator's Brochure
    Clinical and nonclinical
    Informed Consent Form (ICF)
    Master, country, site
    Statistical Analysis Plan (SAP)
    Estimands and CDISC
    Monitoring Documents
    Risk-based monitoring
    Data Management Documents
    DMP and specifications
    DSUR
    ICH E2F annual safety
    Safety Narratives
    Generated at scale
    Development Safety Reports
    Periodic safety reporting
    Clinical Study Report (CSR)
    ICH E3
    Submission Package
    eCTD-ready modules
    eCTD Documents
    Cross-referenced modules
    Why KScribe

    A different way to produce a submission.

    Traditional medical writing
    KScribe
    First complete draft
    Traditional medical writingWeeks to months
    KScribeDays
    Cross-document updates
    Traditional medical writingManual reconciliation
    KScribeAutomatic propagation
    Citations & traceability
    Traditional medical writingHand-checked
    KScribeSource-linked by default
    Regulatory alignment
    Traditional medical writingReviewed after drafting
    KScribeValidated while writing
    Amendments
    Traditional medical writingCascade of rework
    KScribeRe-generated downstream
    Audit trail
    Traditional medical writingReconstructed later
    KScribeCaptured continuously
    Compliance & security

    Enterprise-grade by default. Your data is never used to train models.

    KScribe runs in an isolated tenant with full encryption, access controls, and a complete audit log of every action.

    SOC 2 Type II
    Independently audited controls
    HIPAA
    PHI handled under BAA
    ISO/IEC 27001:2022
    Certified ISMS

    Questions, answered.

    Bring your next submission forward.

    See how KScribe authors your protocol, keeps it aligned with every downstream document, and gets your team to submission-ready faster.